Endocrine Abstracts

Background: Recommendations for the diagnosis of phaeochromocytoma are based on individual institutional experience but have traditionally advocated concurrent measurement of urine and plasma catecholamines. However, reports of phaeochromocytoma presenting with normal catecholamines suggest that this practice is insufficiently sensitive. In phaeochromocytoma there is an increased output of metadrenaline metabolites with a disproprtionate increase in the unconjugated form and e...

The continuous glucose monitoring system (CGMS) have recently been developed for use in diabetes to provide comprehensive blood glucose data around the clock during normal activities. We have demonstrated for the first time that CGMS can assist in the management of 2 patients with confirmed insulinomas. We present 2 female patients (aged 41 and 35 years) with symptoms suggestive of hypoglycaemia. Both had biochemical evidence of insulinoma with hypoglycaemia, hyperinsulinaemia...

The continuous glucose monitoring system (CGMS) have recently been developed for use in diabetes to provide comprehensive blood glucose data around the clock during normal activities. We have demonstrated for the first time that CGMS can assist in the management of 2 patients with confirmed insulinomas. We present 2 female patients (aged 41 and 35 years) with symptoms suggestive of hypoglycaemia. Both had biochemical evidence of insulinoma with hypoglycaemia, hyperinsulinaemia...

Background: Hypoparathyroidism, a rare endocrine disorder characterised by low serum calcium due to low or insufficient parathyroid hormone levels, most commonly occurs post-surgery although can also occur due to predisposing genetic conditions or idiopathically. Hypoparathyroidism requires long-term medical management to minimise complications and detrimental impacts on health-related quality of life. Few real-world studies, particularly in the UK, have quantified healthcare ...

The chicken gonadotropin-releasing hormone receptor (cGnRH-R) is notable for having a cytoplasmic carboxyl-terminal tail, which is not present in the mammalian GnRH-Rs. We have previously shown that the cGnRH-R undergoes rapid agonist-induced internalization, and requires the carboxyl-terminal tail for this process. To investigate the role of the carboxyl-terminal tail of the cGnRH-R in relation to its rapid internalization, and to identify the key residues involved, a series ...